African Community Initiative Support

July 4th, 2009

African Community Initiative Support (ACIS) is a Kenyan-registered charity and NGO, run by Kenyans to serve Kenyans.

The main aim of ACIS is to help the poor in Kenya to improve their living standard by their own hard work, giving them the means to do so, whether it be a small loan (micro-finance), a savings scheme (SACCO), or more practical help.

ACIS endeavours to ensure that any help given to a family or community is ecologically sound.

ACIS also supports children’s institutions that help orphans and children from the poorest backgrounds.

They are presently supporting the Mercy Gate Champion Children’s Home in Kisii and the Silverstone Junior School, Watamu, by finding funds for building work and sponsors for the children.

Loosing Weight In 3

?u?ora

July 3rd, 2009



























?u?ora

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?u?ora is a commune in Ia?i County, Romania. In 2002, it had a population of 2,119. The Battle of Cecora took place here in 1620.

Coordinates: 47°08?N 27°47?E? / ?47.133°N 27.783°E? / 47.133; 27.783

 This Ia?i County location article is a stub. You can help Wikipedia by expanding it.

Retrieved from “http://en.wikipedia.org/wiki/%C5%A2u%C5%A3ora”
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hks ss blowoff valve black

Artemisia vulgaris

July 3rd, 2009

lot craft

Mugwort

Scientific classification
Kingdom: Plantae
(unranked): Angiosperms
(unranked): Eudicots
(unranked): Asterids
Order: Asterales
Family: Asteraceae
Genus: Artemisia
Species: A. vulgaris
Binomial name
Artemisia vulgaris
L.

Artemisia vulgaris (mugwort or common wormwood) is one of several species in the genus Artemisia which have common names that include the word mugwort. This species is also occasionally known as Felon Herb, Chrysanthemum Weed, Wild Wormwood, Old uncle Henry, Sailor’s Tobacco, Naughty Man, Old Man or St. John’s Plant (not to be confused with St John’s wort).

It is native to temperate Europe, Asia and northern Africa, but is also present in North America where it is an invasive weed. It is a very common plant growing on nitrogenous soils, like weedy and uncultivated areas, such as waste places and roadsides.

It is a tall herbaceous perennial plant growing 1-2 m (rarely 2.5 m) tall, with a woody root. The leaves are 5-20 cm long, dark green, pinnate, with dense white tomentose hairs on the underside. The erect stem often has a red-purplish tinge. The rather small flowers (5 mm long) are radially symmetrical with many yellow or dark red petals. The narrow and numerous capitula (flower heads) spread out in racemose panicles. It flowers from July to September.

A number of species of Lepidoptera (butterflies and moths) feed on the leaves and flowers; see List of Lepidoptera that feed on Artemisia for details.

Contents

  • 1 Nomenclature and taxonomy
  • 2 List of the cultivars
  • 3 Etymology
  • 4 Related species
  • 5 Uses
    • 5.1 Food
    • 5.2 Allergen
    • 5.3 Herbal Medicine
    • 5.4 Folklore & Witchcraft
  • 6 References
  • 7 External links

Nomenclature and taxonomy

List of the cultivars

Etymology

Mugwort is often said to derive from the word “mug” because it was used in flavoring drinks. However, this may be a folk etymology. Other sources say Mugwort is derived from the old Norse muggi, meaning “marsh”, and Germanic “wuertz”, meaning “root”, which refers to its use since ancient times to repel insects, especially moths.

Mugwort is called chornobylnik in Ukrainian, and has given its name to the abandoned city of Chornobyl (Chernobyl in Russian). The name chornobyl has an interesting history, meaning “place where mugwort grows” in the related Indo-European languages.

Related species

There are other species in the genus Artemisia called mugwort:

  • Artemisia douglasiana – Douglas’ Mugwort
  • Artemisia glacialis – Alpine Mugwort
  • Artemisia norvegica – Norwegian Mugwort
  • Artemisia princeps – Japanese Mugwort (”Yomogi”)
  • Artemisia stelleriana – Hoary Mugwort
  • Artemisia verlotiorum – Chinese Mugwort

Uses


19th century illustration

Mugwort contains thujone, which is toxic. Thujone is also present in Thuja plicata (western red cedar), from which the name is derived. Pregnant women, in particular, should avoid consuming large amounts of mugwort. The species is little used now due to toxicity concerns, but has a number of recorded historic uses in food, herbal medicine, and as a smoking herb. It is also used by many, as it is thought that placing the herb inside the cover of a pillow and sleeping on the pillow can induce vivid dreams.

Food

The leaves and buds, best picked shortly before the plant flowers in July to September, were used as a bitter flavoring agent to season fat, meat and fish. In Germany, known as Beifuß, it is mainly used to season goose, especially the roast goose traditionally eaten for Christmas. From the German, ancient use of a sprig of mugwort inserted into the goose cavity, comes the saying “goosed” or “is goosed”.

Mugwort is also used in Korea and Japan to give festive rice cakes a greenish color. After the cherry trees bloom in Korea, hordes of bonneted grandmothers collect wild mugwort. It is a common seasoning in Korean soups and pancakes. Known as a blood cleanser, it is believed to have different medicinal properties depending on the region it is collected. In some regions, mugwort thins the blood, while in another region, it is proposed to have hallucigenic properties, leading to some bonneted grandmothers passing out from direct skin contact (dermal absorption) with the active chemicals. For this reason, Koreans also wear a silk sleeve when picking mugwort plants.

In the Middle Ages Mugwort was used as part of a herbal mixture called gruit, used in the flavoring of beer before the widespread introduction of hops. Once again, it is possible that drinkers of the beer were not only intoxicated from the beer, but also from the hallucinogenic properties of the plant.

In Korea, this herb is often used as a flavouring for soft ricecakes (called “sook-dok” or so-ok in current Korean common usage), soups, and other foods. Once cooked, the plant’s hallucinogenic chemicals are neutralized.

Allergen

Mugwort pollen is one of main sources of hay fever and allergic asthma, in North Europe, North America and in parts of Asia.. Mugwort pollen generally travels less than 2000 meters. The highest concentration of mugwort pollen is generally found between 9 and 11 am. The Finnish allergy association recommends tearing as method of eradicating mugwort. Tearing mugwort is known to lessen the effect of the allergy, since the pollen flies only short distance].

Cooking is known to decrease the allergenicity of mugwort, but not enough to make the plant palatable.

Herbal Medicine


A mugwort leaf with the pointed leaves characteristic of a mature plant

The mugwort plant contains ethereal oils (such as cineole, or wormwood oil, and thujone), flavonoids, triterpenes, and coumarin derivatives. It was also used as an anthelminthic, so it is sometimes confused with wormwood (Artemisia absinthium). The plant, called nagadamni in Sanskrit, is used in Ayurveda for cardiac complaints as well as feelings of unease, unwellness and general malaise..

Mugwort is used in the practice of traditional Chinese medicine in a pulverized and aged form called moxa from which we derive the English word ‘moxy’. The British RCT yielded results that indicate that moxibustion of mugwort was indeed effective at increasing the cephalic positioning of fetuses who were in a breech position before the intervention. Since it also causes uterine contractions, it has been used to cause abortion. It also plays a role in Asian traditional medicine as a method of correcting breech presentation. A study of 260 Chinese women at 33 weeks of pregnancy demonstrated cephalic version within two weeks in 75% of fetuses carried by patients who were treated with moxibustion, as opposed to 48% in the control group. It has also been shown that acupuncture plus moxibustion slows fetal heart rates while increasing fetal movement. Two recent studies of Italian patients produced conflicting results. In the first, involving 226 patients, there was cephalic presentation at delivery in 54% of women treated between 33 and 35 weeks with acupuncture and moxibustion, vs. 37% in the control group. The second was terminated prematurely because of numerous coital treatment interruptions.

In rats, Mugwort shows efficacy against trichinellosis.

Folklore & Witchcraft

In the Middle Ages, mugwort was used as a magical protective herb. Mugwort was used to repel insects, especially moths, from gardens. Mugwort has also been used from ancient times as a remedy against fatigue and to protect travelers against evil spirits and wild animals. Roman soldiers put mugwort in their sandals to protect their feet against fatigue. Mugwort is one of the nine herbs invoked in the pagan Anglo-Saxon Nine Herbs Charm, recorded in the 10th century.

Much used in witchcraft, mugwort is said to be useful in inducing lucid dreaming and astral travel. Consumption of the plant, or a tincture thereof, prior to sleeping is said to increase the intensity of dreams, the level of control, and to aid in the recall of dreams upon waking. One common method of ingestion is to smoke the plant.

References

  1. ^ Lust, J. (2005) The Herb Book 604.
  2. ^
  3. ^
  4. ^ a b c
  5. ^ Ramawat, K. G., Ed. (2004). Biotechnology of Medicinal Plants: Vitalizer and Therapeutic Enfield, New Hampshire: Science Publishers, Inc. 5.
  6. ^ Cardini, F., and W. X. Huang. JAMA 280(18): 1580-1584, November 1998
  7. ^ Neri, I., et al. Journal of the Society for Gynecological Investigation 9(3): 158-162, May-June 2002
  8. ^ Neri, I., et al. Journal of Maternal-Fetal and Neonatal Medicine 15(4): 247-252
  9. ^ Cardini, F., et al. BJOG 112(6): 743-747, June 2005
  10. ^ Caner A, Dö?kaya M, De?irmenci A, et al. (May 2008). “Comparison of the effects of Artemisia vulgaris and Artemisia absinthium growing in western Anatolia against trichinellosis (Trichinella spiralis) in rats”. Exp. Parasitol. 119 (1): 173–9. doi:10.1016/j.exppara.2008.01.012. PMID 18325496. 
  11. ^ Wright, Colin, Ed. (2002). Artemisia. London; New York: Taylor & Francis. pp. 144. ISBN 0-415-27212-2. http://books.google.com/books?id=t0MtnKDvLLwC&pg=PA144&lpg=PA144&dq=roman+soldiers+mugwort&source=web&ots=DqA5fkbz4W&sig=wHxgVLH6bu_ytzvSj5CpLGmzLws#PPA145,M1. 

bisque

Sydney Push

July 3rd, 2009


The Royal George building in April, 2004. It has been renamed the Slip Inn. The Sydney Push met in the “back room”, a little above ground floor, at left.

The Sydney Push was a predominantly left-wing intellectual sub-culture in Sydney from the late 1940s to the early ’70s. Well known associates of The Push include John Flaus, Harry Hooton, Margaret Fink, Sasha Soldatow, Lex Banning, Eva Cox, Peter Hamilton, Paddy McGuinness, David Makinson, Germaine Greer, Clive James, Robert Hughes, Frank Moorhouse and Lillian Roxon. In 1961-2, poet Les Murray resided in Brian Jenkins’s Push household at Glen Street, Milsons Point, which became a mecca for associates visiting Sydney from Melbourne and other cities.

The Push operated in a pub culture and comprised a broad range of manual workers, musicians, lawyers, criminals, journalists and public servants as well as staff and students of Sydney University—predominantly though not exclusively in the Faculty of Arts. Rejection of conventional morality and authoritarianism formed their main common bond. From the mid-1960s, people from the New South Wales University of Technology (later renamed the University of New South Wales) also became involved.

Contents

  • 1 Academic contributors
  • 2 Social and cultural life
  • 3 Protest and activism
  • 4 Events in the news
  • 5 Dispersal after 1964
  • 6 References
  • 7 Bibliography
  • 8 External links

Academic contributors

Some of the key intellectual figures in Push debates included philosophers David J. Ivison, George Molnar, Roelof Smilde, Darcy Waters and Jim Baker, as recorded in Baker’s memoir Sydney Libertarians and the Push, published in Libertarian Broadsheet in 1975. Other active people included psychologists Terry McMullen and Geoff Whiteman, educationist David Ferraro, June Wilson, Les Hiatt, Ian Bedford, Ken Maddock and Alan Olding, among many others listed in the article. An understanding of libertarian values and social theory can be obtained from their publications, a few of which are available online. There are also interesting critical articles in the Arts Society’s annual journal Arna by Baker and Molnar whose essay on Zamyatin’s We concluded:

. . . Orwell spins out to its last conclusion the illusion that the fate of freedom depends mainly on the colour of the ruling party. “We”, precisely because it presents its rebels as apolitical, as individualists if you wish, cuts through this falsehood. Zamyatin’s superior social insight, although presented and presumably gained artistically and not by way of scientific analysis, consists first in his firm rejection of the rationality or finality of history and, second, in his recognition that anarchic protest against those in power, not the capture of power, is at the core of freedom.

A representative collection of Sydney Libertarian essays was published by L. R. Hiatt in The Sydney Line, printed in 1963 by the Hellenic Herald, whose proprietor Nestor Grivas was a prominent non-academic Push personality and champion of sexual freedom.

John Anderson, the Scottish-born Challis Professor of Philosophy at Sydney University from 1927 until his retirement in 1958, was seminal in the formation of Sydney Libertarianism of which, however, he vigorously disapproved. In 1951, a group of his disciples, led by Jim Baker, had formed a proactive faction which split Anderson’s Free Thought Society. They asserted that it was natural and desirable for critical thought to engender commensurate action, the principle on which the Libertarian Society was launched.

Social and cultural life

The intellectual life of the Libertarians was mainly pursued in and around the university, including neighbouring pubs like May’s, the Forest Lodge and the British Lion. On evenings and weekends, it overflowed into the much larger ‘downtown’ social milieu known as the Push, which flourished at a succession of pubs and other places of refreshment including the Tudor, Lincoln, Lorenzini’s Wine Bar, Repin’s Coffee Shop and, of greatest notoriety, the Royal George Hotel in Sussex Street.

Since the mid-1950s, before extended pub hours replaced 6 o’clock closing, Push nightlife commonly consisted of a meal at an inexpensive restaurant such as the Athenian or Hellenic Club (”the Greeks”) or La Veneziana (”the Italians”) followed by parties held most nights of the week at private residences. These were very lively occasions with singing of folksongs and bawdy ditties such as ‘Professor John Glaister’ and many others. Accompaniments were provided by accomplished guitarists and lutenists (Ian McDougall, John Earls, Terry Driscoll, Don Ayrton, Brian Mooney, Don Lee, Beth Schurr, Bill Berry, Marian Henderson and others). Don Henderson, Declan Affley and Martyn Wyndham-Read are but three well-known artists who learned much in the Push.

Protest and activism


Sydney Push associates Ian Parker (left) and Bob Gould in a 1960s pavement demonstration outside the Queen Victoria Building. Parker has since died; Gould is a bookseller .

Sydney Libertarianism adopted an attitude of permanent protest recognisable in the sociological theories of Max Nomad, Vilfredo Pareto and Robert Michels, which predicted the inevitability of elites and the futility of revolutions. They used phrases such as “anarchism without ends,” “non-utopian anarchism,” and “permanent protest” to describe their activities and theories. Others labelled them as the ‘futilitarians’. An early Marx quotation, used by Wilhelm Reich as the motto for his The Sexual Revolution, was adopted as a motto vis:

“Since it is not for us to create a plan for the future that will hold for all time, all the more surely what we contemporaries have to do is the uncompromising critical evaluation of all that exists, uncompromising in the sense that our criticism fears neither its own results nor the conflict with the powers that be.”

Nevertheless, Push associates regularly assisted in organising and turning out for street demonstrations, e.g., against South African apartheid and in support of victims of the 1960 Sharpeville massacre; against the initial refusal of immigration minister Alexander Downer, Snr to grant political asylum to three Portuguese merchant seamen who jumped ship in Darwin; and against Australia’s participation in the Vietnam War.

In line with the Libertarians’ rejection of conventional political models, electoral activism was foreign to the Push, save to urge non-voting and informal voting. At the election after prime minister Harold Holt failed to return from a swim, artist and film-maker David Perry produced a highly acclaimed poster featuring a stylised pig wearing a bow tie. Its message was Whoever you vote for, a politician always gets in!

Events in the news

The most dramatic public event to impinge on the Push was the mysterious Bogle-Chandler case of 1963 and its sequel, a heavily publicised inquest in which several Push personalities gave evidence. Another memorable incident involved the discovery of what news media recognised as a dismembered murder victim in an unlocked trunk at the foot of a city train-station escalator. This was later revealed to be a collection of body parts, the property of a doctor, found and used in a macabre practical joke by a notorious confidence trickster, the late Ashleigh Sellors (known in the Push as ‘Flash Ash’).

Dispersal after 1964

The year 1964 saw the gradual demise of the Royal George Hotel as the prime focal venue of the Sydney Push which dispersed its bustling social life to other traditional venues like the Newcastle, Orient and Port Jackson hotels in The Rocks near Circular Quay and the Rose, Crown and Thistle at Paddington, but also to alternative central-city pubs including the United States and Edinburgh Castle. By the early 1970s, the Criterion Hotel on the corner of Liverpool and Sussex Streets had become the watering hole of the last of the Push diehards. Meanwhile, Push hangers-on and ‘tourists’, now numbering hundreds, patronised pubs like the Four-in-Hand (Paddington) and the Forth and Clyde at Balmain, but these were venues of social entertainment, lacking the intellectual cameraderie, the informal folksong and the bohemian flavour of the ‘George’.

The retired education professor Alan Barcan has published a personal account of his view of activism at Sydney University during the 1960s. Though he was not an eyewitness of Push life, he provides some relevant insights into how student life became infected by Push doctrines of freedom and rebellion, to a point at which the social movement was superseded and its leading personalities were dispersed or replaced with a new breed of social critics.. As described by Barcan, this period saw the emergence of mainstream talents like poets Les Murray and Geoffrey Lehmann, journalists David Solomon, Mungo MacCallum (Jnr) and Laurie Oakes, Oz magazine satirists Richard Neville, Richard Walsh and Martin Sharp, and maverick writer Bob Ellis. These were people who did not actively embrace the Push life but were strongly influenced by it.

Push personalities who emigrated to the United Kingdom included Clive James, Paddy McGuinness, Chester (Phillip Graham) and Ian Parker (pictured above) who was knocked down and killed by a bus while drunk in a London street. Paddy McGuinness returned to Australia in 1971, working as a film critic, Labor ministerial staffer, right-wing newspaper columnist and journal editor until his death in 2007. Folksinger John Earls went to Bolivia and former Tribune (Communist Party of Australia newspaper) cartoonist Harry Reade went to join Fidel Castro’s revolution in Cuba (and returned in 1971 at the same time as Paddy McGuinness). The disabled poet Lex Banning travelled to England and Greece in 1962-64 but returned and died in Sydney in 1965. The accomplished folksinger Don Ayrton departed to settle at Kuranda in Queensland where he committed suicide in 1982. A grievous tragedy occurred as Paddy McGuinness was departing to Italy aboard a ship in May 1963. The farewelling crowd included an attractive young Push lady, Janne Millar, who fell to the concrete dock floor from a height and suffered fatal head injuries. A number of other tragic deaths occurred in this decade, including some from substance abuse which was becoming a regular part of Sydney culture at the time.

It must also be recorded that many talented young associates simply moved on to careers in the professions and academia. Few will ever forget the supplementary education they received from the Push. A reunion organised by André Frankovits at the Royal George/Slip Inn in 2000 attracted over 100.

On the demise of the Push, Anne Coombs has stated: in 1964, the year the Beatles came and brought into the open that new phenomenon: ‘youth culture’. Citing this, Alan Barcan added “In advocating free love and opposition to authority, the Push and the Libertarians anticipated the new post-1968 morality. But the adoption of many of their ideas by society undermined their raison d’être.

References

  1. ^ A 1970s associate, subject of David Marr’s A spirit gone to another place SMH obituary, Sep 9 2006
  2. ^ Alexander Peter F. Les Murray: a Life in Progress, Oxford University Press UK, 2000
  3. ^ See Baker A J Sydney Libertarianism and the Push or at—
  4. ^ Sydney Libertarians and the Push on Prof. W L Morison memorial site
  5. ^ Articles and Essays of and by Sydney Libertarians
  6. ^ Sydney Libertarianism at the Marxists Internet Archive
  7. ^ Baker A. J. The Politics of 1984 pp. 34-43, Arna (S.U. Arts Society, 1958)
  8. ^ Molnar, George Zamyatin’s “We”—a libertarian viewpoint pp. 11-20 , Arna (S.U. Arts Society, 1961)
  9. ^ S Hogbotel & S Fuckes (1973). Snatches & Lays — Songs Miss Lilly White should never have taught us. Sun Books, Melbourne. ISBN 0-7251-0164-4. 
  10. ^ Fahey, W Key players on the Sydney coffee lounge scene In Australian Folklore Unit
  11. ^ Making of a song-writer—interview
  12. ^ Martyn Wyndham-Read official site
  13. ^ Bogle and Chandler–a factual website with bibliography
  14. ^ a b Barcan, A Student activists at Sydney University 1960-1967
  15. ^ who sailed on the Bretagne, New Year’s Eve, 1961, as recorded in his Unreliable Memoirs (1980) p. 166
  16. ^ Bob Gould The life and times of Paddy McGuinness and Bob Gould Statement at the funeral of P P McGuinness, Feb 2008
  17. ^ a b Anne Coombs (1996). Sex and Anarchy: The Life and Death of the Sydney Push. Ringwood, Vic. : Viking. ISBN 0-670-87069-2. 

Bibliography

  • A.J. Baker (1979). Anderson’s Social Philosophy: The Social Thought and Political Life of Professor John Anderson. Sydney, N.S.W. : Angus & Robertson Publishers. ISBN 0-207-14216-5. 
  • A.J. Baker (1997). Social Pluralism: A Realistic Analysis. Glebe, N.S.W. : Wild and Woolley. ISBN 0-646-32616-3. 
  • Alan Barcan (2002). Radical Students: The Old Left at Sydney University. Carlton South, Vic. : Melbourne University Press. ISBN 0-522-85017-0. 
  • Anne Coombs (1996). Sex and Anarchy: The Life and Death of the Sydney Push. Ringwood, Vic. : Viking. ISBN 0-670-87069-2. 
  • James Franklin (2003). Corrupting the Youth: A History of Philosophy in Australia. Sydney : Macleay Press. ISBN 1876492082. , ch. 8.
  • Brian Kennedy (1995). A Passion to Oppose: John Anderson, Philosopher. Carlton South, Vic. : Melbourne University Press. ISBN 0-522-84683-1. 
  • Libertarian Nos 1-3. Libertarian Society at Sydney University. 1957-1960. 
  • Judy Ogilvie (1995). The Push: An Impressionist Memoir. Leichhardt, N.S.W. : Primavera Press. ISBN 0-9589494-8-4. 
  • The Sydney Line. ed. L R Hiatt, printed at the Hellenic Herald. 1963. 

Over Weight Guy

P110?

July 3rd, 2009

pocket bikes

edit
Phosphoinositide-3-kinase, catalytic, alpha polypeptide
PI3 Kinase 110 alpha bound to the inhibitor PIK-93 (yellow).
Identifiers
Symbols PIK3CA; MGC142161; MGC142163; PI3K; p110-alpha
External IDs OMIM: 171834 MGI: 1206581 HomoloGene: 21249
RNA expression pattern

More reference expression data

Orthologs
Human Mouse
Entrez 5290 18706
Ensembl ENSG00000121879 ENSMUSG00000027665
Uniprot P42336 Q0VGQ5
Refseq NM_006218 (mRNA)
NP_006209 (protein)
NM_008839 (mRNA)
NP_032865 (protein)
Location Chr 3: 180.35 - 180.44 Mb Chr 3: 32.63 - 32.65 Mb
Pubmed search

The p110? protein is a class I PI 3-kinase catalytic subunit. The human p110? protein is encoded by the PIK3CA gene.

Contents

  • 1 Function
  • 2 Clinical significance
  • 3 See also
  • 4 References
  • 5 Further reading

Function

Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate phosphatidylinositols (PtdIns), PtdIns4P and PtdIns(4,5)P2.

Clinical significance

This gene has been found to be oncogenic and has been implicated in cervical cancers. Recent evidence has shown that the PIK3CA gene is mutated in a range of human cancers. Due to the association between p110? and cancer it is believed to be a promising drug target. A number of pharmaceutical companies are currently designing and charactering potential p110? isoform specific inhibitors.

See also

  • Phosphoinositide 3-kinase

References

  1. ^ Hiles ID, Otsu M, Volinia S, Fry MJ, Gout I, Dhand R, Panayotou G, Ruiz-Larrea F, Thompson A, Totty NF (August 1992). “Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit”. Cell 70 (3): 419–29. doi:10.1016/0092-8674(92)90166-A. PMID 1322797. 
  2. ^ “Entrez Gene: PIK3CA”. http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5290. 
  3. ^ Ma YY, Wei SJ, Lin YC, Lung JC, Chang TC, Whang-Peng J, Liu JM, Yang DM, Yang WK, Shen CY (May 2000). “PIK3CA as an oncogene in cervical cancer”. Oncogene 19 (23): 2739–44. doi:10.1038/sj.onc.1203597. PMID 10851074. 
  4. ^ Samuels Y, Wang Z, Bardelli A, Silliman N, Ptak J, Szabo S, Yan H, Gazdar A, Powell SM, Riggins GJ, Willson JK, Markowitz S, Kinzler KW, Vogelstein B, Velculescu VE (April 2004). “High frequency of mutations of the PIK3CA gene in human cancers”. Science (New York, N.Y.) 304 (5670): 554. doi:10.1126/science.1096502. PMID 15016963. 
  5. ^ Stein RC (September 2001). “Prospects for phosphoinositide 3-kinase inhibition as a cancer treatment”. Endocrine-related Cancer 8 (3): 237–48. doi:10.1677/erc.0.0080237. PMID 11566615. 
  6. ^ Marone R, Cmiljanovic V, Giese B, Wymann MP (January 2008). “Targeting phosphoinositide 3-kinase: moving towards therapy”. Biochimica Et Biophysica Acta 1784 (1): 159–85. doi:10.1016/j.bbapap.2007.10.003. PMID 17997386. 

architecture

Pennsylvania Route 2

July 3rd, 2009

used nib

PA Route 2
Lackawanna Trail
Existed: 1924 – 1930
Pennsylvania State Routes
< PA 1 PA 3 >
Minor - Legislative

The former Pennsylvania Route 2 was formed in 1924, and ran south to north from Philadelphia to the New York state line for a distance of 163 miles (262 km). The route passed through Philadelphia, Montgomery, Bucks, Northampton, Monroe, Wayne, Lackawanna, Wyoming, and Susquehanna Counties.

Deleted in 1930, PA 2 followed the former U.S. Route 611, now PA Route 611, from Philadelphia, to Scranton, and the current U.S. Route 11 from there to the New York state line near Great Bend.

mercedes

China Shipbuilding Industry Corporation

July 3rd, 2009

arthur

China Shipbuilding Industry Corporation
??????????
Type State-owned enterprise
Founded 1999
Headquarters Flag of the People's Republic of China Beijing, China
Area served China
Key people Party secretary and General president: Li Changyin
Industry Shipbuilding
Website China Shipbuilding Industry Corporation
China CSSC Holdings Limited
????????????
Type State-owned enterprise
Founded 2008
Headquarters Flag of the People's Republic of China Beijing, China
Area served China
Key people Chairman: Li Changyin
Industry Shipbuilding
Parent China Shipbuilding Industry Corporation
Website China Shipbuilding Industry Company Limited

The China Shipbuilding Industry Corporation (CSIC) is one of the two largest shipbuilding conglomerates in China, the other being the China State Shipbuilding Corporation (CSSC). It was formed by the Government on 1 July 1999 from companies spun off from CSSC. It is headquartered in Beijing. Its trade arm is China Shipbuilding & Offshore International Co. Ltd.

CSIC’s subsidiary, China Shipbuilding Industry Company Limited, was listed on the Shanghai Stock Exchange in 2008.

pillow cases

Elections in French Polynesia

July 3rd, 2009

French Polynesia

This article is part of the series:
Politics and government of
French Polynesia


  • High Commissioner
    • Adolphe Colrat
  • President
    • Oscar Temaru
  • Assembly
    • Assembly President
      • Philip Schyle
  • Political parties
  • Elections
    • 2008
    • Presidential 2009
  • Administrative divisions

Other countries · Atlas
 Politics portal
view  talk  edit

Elections in French Polynesia gives information on election and election results in French Polynesia.

French Polynesia elects the Assembly of French Polynesia (Assemblée de la Polynésie française), the unicameral legislature on the territorial level. The Assembly of French Polynesia has 57 members, elected for a five year term by proportional representation in multi-seat constituencies. French Polynesia has a two-party system, which means that there are two dominant political parties, with extreme difficulty for anybody to achieve electoral success under the banner of any other party.

Contents

  • 1 Last elections
  • 2 Past elections
  • 3 2007 elections
  • 4 2008 elections
  • 5 See also
  • 6 References

Last elections

Main article: French Polynesian legislative election, 2004


Summary of the 23 May 2004 and 13 February 2005 Assembly of French Polynesia election results
Alliances and parties Votes % Seats
Tahoera’a Huiraatira (Popular Rally) 45.2 27
Union for the Democracy (Union pour la Démocratie)

  • Tavini Huiraatira (People’s Servant)
  • Aia Api (New Land)
  • Here Ai’a (Love the Land)
  • Tapura Amui No Te Faatereraa Manahune - Tuhaa Pae
  • Tapura Amui No Raromatai
49.1 28
Alliance for a New Democracy (Alliance pour une Démocratie Nouvelle)

  • Fetia Api (Nouvelle Etoile/New Star)
  • No Oe E Te Nunaa (This Country is Yours)
2
Total (turnout 78.3 %)   57
Source: Rulers. By-elections were held 13 February 2005 in Tahiti and Moorea after the election was invalidated in these districts (37 of the total 57 seats).

Past elections

2007 elections

On September 14, 2007, Oscar Temaru, 63, was elected president of French Polynesia for the 3rd time in 3 years (with 27 of 44 votes cast in Tahiti assembly). He replaced former President Gaston Tong Sang, who lost a no-confidence vote in the 31 August parliament.

2008 elections

Main article: French Polynesian legislative election, 2008

In the elections on January 27 and February 10, 2008, the To Tatou Ai’a (Our Land) party led by Gaston Tong Song, Mayor of Bora Bora, won 29 seats out of the 66 possible but not the overall majority. The Union for Democracy (Union pour la Démocratie) which included Oscar Temaru’s pro-independence Tavini Huiraatira gained 20 seats. A surprise coalition between old enemies Gaston Flosse (Tahoera’a Huiraatira, 10 seats) and Temaru saw once again the election of Flosse as President of French Polynesia.

See also

  • Electoral calendar
  • Electoral system

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Lumbar puncture

July 3rd, 2009


A patient undergoes a lumbar puncture at the hands of a neurologist. The reddish-brown swirls on the patient’s back are tincture of iodine (an antiseptic).

In medicine, a lumbar puncture (colloquially known as a spinal tap) is a diagnostic and at times therapeutic procedure that is performed in order to collect a sample of cerebrospinal fluid (CSF) for biochemical, microbiological, and cytological analysis, or very rarely as a treatment (”therapeutic lumbar puncture”) to relieve increased intracranial pressure.

Contents

  • 1 Indications
  • 2 Contraindications
  • 3 Procedure
  • 4 Risks
  • 5 Diagnostics
  • 6 History
  • 7 References
  • 8 External links

Indications

The most common purpose for a lumbar puncture is to collect cerebrospinal fluid in a case of suspected meningitis, since there is no other reliable tool with which meningitis, a life-threatening but highly treatable condition, can be excluded. Young infants commonly require lumbar puncture as a part of the routine workup for fever without a source, as they have a much higher risk of meningitis than older persons and do not reliably show signs of meningeal irritation (meningismus). In any age group, subarachnoid hemorrhage, hydrocephalus, benign intracranial hypertension and many other diagnoses may be supported or excluded with this test.

Lumbar punctures may also be done to inject medications into the cerebrospinal fluid (”intrathecally”), particularly for spinal anesthesia or chemotherapy. Lumbar punctures can be unpleasant for some people, due to increased sensitivity when the needle is inserted to collect the cerebrospinal fluid.

Contraindications

Lumbar puncture should not be performed when idiopathic (unidentified cause) increased intracranial pressure (ICP) is present. The exception is therapeutic use of lumbar puncture to relieve ICP. Ideally, a CT scan should be performed prior to lumbar puncture to rule out space occupying lesions. Lumbar puncture should not be attempted when there is coagulopathy, or when there are decreased levels of platelets in the blood (less than 50 x 109/L). Lumbar puncture in cases of vertebral deformities(scoliosis or kyphosis) is also contraindicated in hands of an unexperienced physician.

Procedure


Spinal needles used in lumbar puncture.

In performing a lumbar puncture, first the patient is usually placed in a left (or right) lateral position with his/her neck bent in full flexion and knees bent in full flexion up to his/her chest, approximating a fetal position as much as possible. It is also possible to have the patient sit on a stool and bend his/her head and shoulders forward. The area around the lower back is prepared using aseptic technique. Once the appropriate location is palpated, local anaesthetic is infiltrated under the skin and then injected along the intended path of the spinal needle. A spinal needle is inserted between the lumbar vertebrae L3/L4 or L4/L5 and pushed in until there is a “give” that indicates the needle is past the dura mater. The stylet from the spinal needle is then withdrawn and drops of cerebrospinal fluid are collected. The opening pressure of the cerebrospinal fluid may be taken during this collection by using a simple column manometer. The procedure is ended by withdrawing the needle while placing pressure on the puncture site. In the past, the patient would often be asked to lie on his/her back for at least six hours and be monitored for signs of neurological problems, though there is no scientific evidence that this provides any benefit. The technique described is almost identical to that used in spinal anesthesia, except that spinal anesthesia is more often done with the patient in a sitting position.

The upright seated position is advantageous in that there is less distortion of spinal anatomy which allows for easier withdrawal of fluid. It is preferred by some practitioners when a lumbar puncture is performed on an obese patient where having them lie on their side would cause a scoliosis and unreliable anatomical landmarks. On the other hand, opening pressures are notoriously unreliable when measured on a seated patient and therefore the left or right lateral (lying down) position is preferred if an opening pressure needs to be measured.

Patient anxiety during the procedure can lead to increased CSF pressure, especially if the person holds their breath, tenses their muscles or flexes their knees too tightly against their chest. Diagnostic analysis of changes in fluid pressure during lumbar puncture procedures requires attention both to the patient’s condition during the procedure and to their medical history.

Reinsertion of the stylet may decrease the rate of post lumbar puncture headaches.

Risks

Headache with nausea is the most common complication; it often responds to analgesics and infusion of fluids and can often be prevented by strict maintenance of a supine posture for two hours after the successful puncture. Merritt’s Neurology (10th edition), in the section on lumbar puncture, notes that intravenous caffeine injection is often quite effective in aborting these so-called “spinal headaches.” Contact between the side of the lumbar puncture needle and a spinal nerve root can result in anomalous sensations (paresthesia) in a leg during the procedure; this is harmless and patients can be warned about it in advance to minimize their anxiety if it should occur. A headache that is persistent despite a long period of bedrest and occurs only when sitting up may be indicative of a CSF leak from the lumbar puncture site. It can be treated by more bedrest, or by an epidural blood patch, where the patient’s own blood is injected back into the site of leakage to cause a clot to form and seal off the leak.

Serious complications of a properly performed lumbar puncture are extremely rare. They include spinal or epidural bleeding, and trauma to the spinal cord or spinal nerve roots resulting in weakness or loss of sensation, or even paraplegia. The latter is exceedingly rare, since the level at which the spinal cord ends (normally the inferior border of L1, although it is slightly lower in infants) is several vertebral spaces above the proper location for a lumbar puncture (L3/L4). There are case reports of lumbar puncture resulting in perforation of abnormal dural arterio-venous malformations, resulting in catastrophic epidural hemorrhage; this is exceedingly rare.

The procedure is not recommended when epidural infection is present or suspected, when topical infections or dermatological conditions pose a risk of infection at the puncture site or in patients with severe psychosis or neurosis with back pain. Some authorities believe that withdrawal of fluid when initial pressures are abnormal could result in spinal cord compression or cerebral herniation; others believe that such events are merely coincidental in time, occurring independently as a result of the same pathology that the lumbar puncture was performed to diagnose. In any case, computed tomography of the brain is often performed prior to lumbar puncture if an intracranial mass is suspected.

Removal of cerebrospinal fluid resulting in reduced fluid pressure has been shown to correlate with greater reduction of cerebral blood flow among patients with Alzheimer’s disease. Its clinical significance is uncertain.

Diagnostics

Increased CSF pressure can indicate congestive heart failure, cerebral edema, subarachnoid hemorrhage, hypo-osmolality resulting from hemodialysis, meningeal inflammation, purulent meningitis or tuberculous meningitis, hydrocephalus, or pseudotumor cerebri.

Decreased CSF pressure can indicate complete subarachnoid blockage, leakage of spinal fluid, severe dehydration, hyperosmolality, or circulatory collapse. Significant changes in pressure during the procedure can indicate tumors or spinal blockage resulting in a large pool of CSF, or hydrocephalus associated with large volumes of CSF. Lumbar puncture for the purpose of reducing pressure is performed in some patients with idiopathic intracranial hypertension (also called pseudotumor cerebri.)

The presence of white blood cells in cerebrospinal fluid is called pleocytosis. A small number of monocytes can be normal; the presence of granulocytes is always an abnormal finding. A large number of granulocytes often heralds bacterial meningitis. White cells can also indicate reaction to repeated lumbar punctures, reactions to prior injections of medicines or dyes, central nervous system hemorrhage, leukemia, recent epileptic seizure, or a metastatic tumor. When peripheral blood contaminates the withdrawn CSF, a common procedural complication, white blood cells will be present along with erythrocytes, and their ratio will be the same as that in the peripheral blood.

Several substances found in cerebrospinal fluid are available for diagnostic measurement.

  • Measurement of chloride levels may aid in detecting the presence of tuberculous meningitis.
  • Glucose is usually present in the CSF; the level is usually about 60% that in the peripheral circulation. A fingerstick or venipuncture at the time of lumbar puncture may therefore be performed to assess peripheral glucose levels in order to determine a predicted CSF glucose value. Decreased glucose levels can indicate fungal, tuburculous or pyogenic infections; lymphomas; leukemia spreading to the meninges; meningoencephalitic mumps; or hypoglycemia. A glucose level of less than one third of blood glucose levels in association with low CSF lactate levels is typical in hereditary CSF glucose transporter deficiency.
  • Increased glucose levels in the fluid can indicate diabetes, although the 60% rule still applies.
  • Increased levels of glutamine are often involved with hepatic encephalopathies, Reye’s syndrome, hepatic coma, cirrhosis and hypercapnia.
  • Increased levels of lactate can occur the presence of cancer of the CNS, multiple sclerosis, heritable mitochondrial disease, low blood pressure, low serum phosphorus, respiratory alkalosis, idiopathic seizures, traumatic brain injury, cerebral ischemia, brain abscess, hydrocephalus, hypocapnia or bacterial meningitis.
  • The enzyme lactate dehydrogenase can be measured to help distinguish meningitides of bacterial origin, which are often associated with high levels of the enzyme, from those of viral origin in which the enzyme is low or absent.
  • Changes in total protein content of cerebrospinal fluid can result from pathologically increased permeability of the blood-cerebrospinal fluid barrier, obstructions of CSF circulation, meningitis, neurosyphilis, brain abscesses, subarachnoid hemorrhage, polio, collagen disease or Guillain-Barré syndrome, leakage of CSF, increases in intracranial pressure or hyperthyroidism. Very high levels of protein may indicate tuberculous meningitis or spinal block.
  • IgG synthetic rate is calculated from measured IgG and total protein levels; it is elevated in immune disorders such as multiple sclerosis, transverse myelitis, and neuromyelitis optica of Devic.
  • Numerous antibody-mediated tests for CSF are available in some countries: these include rapid tests for antigens of common bacterial pathogens, treponemal titers for the diagnosis of neurosyphilis and Lyme disease, Coccidioides antibody, and others.
  • The India ink test is still used for detection of meningitis caused by Cryptococcus neoformans, but the cryptococcal antigen (CrAg) test has a higher sensitivity.
  • CSF can be sent to the microbiology lab for various types of smears and cultures to diagnose infections.
  • Polymerase chain reaction (PCR) has been a great advance in the diagnosis of some types of meningitis. It has high sensitivity and specificity for many infections of the CNS, is fast, and can be done with small volumes of CSF. Even though testing is expensive, it saves cost of hospitalization.

History

The first technique for accessing the dural space was described by the London physician Dr Walter Essex Wynter. In 1889, he developed a crude cut down with cannulation in 4 patients with tuberculous meningitis. The main purpose was the treatment of raised intracranial pressure rather than for diagnosis. The technique for needle lumbar puncture was then introduced by the German physician Heinrich Quincke, who credits Wynter with the earlier discovery; he first reported his experiences at an internal medicine conference in Wiesbaden in 1891. He subsequently published a book on the subject.

The lumbar puncture procedure was taken to the United States by Arthur H. Wentworth M.D., an assistant professor at the Harvard Medical School, based at Children’s Hospital. In 1893, he published a long paper on diagnosing cerebro-spinal meningitis by examining spinal fluid. His career took a nosedive, however, when the antivivisectionists prosecuted him for having obtained spinal fluid from children. He was acquitted, but he was disinvited from the then forming Johns Hopkins Medical School where he would have been the first professor of pediatrics.

References

  1. ^ Roos KL (March 2003). “Lumbar puncture”. Semin Neurol 23 (1): 105–14. doi:10.1055/s-2003-40758. PMID 12870112. 
  2. ^ a b Straus SE, Thorpe KE, Holroyd-Leduc J (October 2006). “How do I perform a lumbar puncture and analyze the results to diagnose bacterial meningitis?”. JAMA 296 (16): 2012–22. doi:10.1001/jama.296.16.2012. PMID 17062865. 
  3. ^ Wynter WE (1891). “Four cases of tubercular meningitis in which paracentesis of the theca vertebralis was performed for the relief of fluid pressure”. Lancet 1: 981–2. doi:10.1016/S0140-6736(02)16784-5. 
  4. ^ Quincke HI (1891). Verhandlungen des Congresses für Innere Medizin, Zehnter Congress, Wiesbaden. 10. pp. 321–331. 
  5. ^ Quincke HI (1902). Die Technik der Lumbalpunktion. Berlin & Vienna. 
  6. ^ Heinrich Irenaeus Quincke at Who Named It?

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Bonthorpe

July 3rd, 2009



























Bonthorpe

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Bonthorpe is a tiny hamlet north east of Willoughby, Lincolnshire. There are a handful of houses, two farms and an elderly residential home.

  This Lincolnshire location article is a stub. You can help Wikipedia by expanding it.

Retrieved from “http://en.wikipedia.org/wiki/Bonthorpe”
Categories: Villages in Lincolnshire | Lincolnshire geography stubsHidden categories: Lincolnshire articles missing geocoordinate data

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